EFEKTIVITAS PEMBERIAN SALEP EKSTRAK DAUN CENGKEH (Syzygium Aromaticum L.) TERHADAP JUMLAH SEL FIBROBLAS PADA PENYEMBUHAN LUKA INSISI TIKUS GALUR WISTAR (Rattus norvegicus)

An open wound is a condition where part of the body's tissue has been damaged from its normal state due to sharp or blunt trauma, changes in temperature, chemicals, explosions, electric shock or animal bites. Clove leaves contain active ingredients such as eugenol saponins, phenols, steroids, terpenoids, alkaloids, flavonoids and tannins and essential oils which have the potential to be anti�inflammatory, antibacterial and analgesic in inhibiting cell damage and speeding up the healing process in wounds. The aim of this study was to test the effectiveness of administering clove leaf extract ointment in the healing process of incisional wounds by observing the number of fibroblast cells in Wistar rats (Rattus norvegicus). This type of research is an in vivo laboratory experiment with a post test only control group design and sample grouping using a Completely Randomized Design (CRD). The treatment was carried out for 5 days by applying it to the mice's backs twice a day, then on the 6th day, decaputation was carried out, taking specimens to observe the number of fibroblast cells. The research was analyzed using one way ANOVA followed by the Least Significant Difference (LSD) test. The results of the study showed that administering clove leaf extract ointment (Syzygium Aromaticum L.) with concentrations of 3%, 6% and 9% was effective in increasing the number of fibroblast cells in the healing process of incisional wounds on the backs of Wistar rats (Rattus norvegicus). Conclusion: Giving clove leaf extract ointment at a concentration of 3% is more effective in increasing the number of fibroblast cells in the healing process of incisional wounds in mice compared to concentrations of 6% and 9%.