Phytochemical Screening and in Vivo Test of Dewandaru (Eugenia uniflora L) Fruit Extract on Mice Exposed to Cigarette Smoke

Cigarette smoke contains various toxic chemical compounds which can trigger oxidative stress. Biomarkers to show the degree of oxidative stress that occurs are levels of malondialdehyde (MDA) The n-butanol extract of Eugenia uniflora fruit contains compounds that have antioxidant activity of phenolic and non-phenolic compounds. The purpose of this study was phytochemical screening and the effect of giving n-butanol extract of fruit Eugenia uniflora L on oxidative stress mice exposed to cigarette smoke. The research design was an experimental randomized post-test control group design, The control group of mice was only given exposure to cigarette smoke 1 stick per day (K), the second group was given exposure to cigarette smoke 1 stick per day P1 dose of 100 mg /KgBB, the third group was given exposure to cigarette smoke 1 stick per day P2 dose 200 mg /KgBB, n-butanol Dewandaru fruit extract. The treatment of experimental animals was given for 30 days, malondialdehyde was analyzed using the Elisa method