Efficacy of Bidara Leaf (Ziziphus Mauritiana) Viscous Extract to Gingival Wound Healing in Wistar Rats

This study aims to determine the efficacy of bidara leaf (Ziziphus mauritiana) viscous extract to accelerate wound healing in the gingiva of Wistar rats (Rattus norvegicus). The method used is an in-vivo experimental laboratory with a post-test-only control group design. Three groups of bidara leaf extract were made with different viscosities (100%, 80% and 70%) in a gel form, and 10% Povidone-iodine as a control group. Forty male Wistar rats were applied gel extract on the gingival wound according to the group, twice a day. On the 8th day, the animal’s study were decapitated and continued with a histological examination procedure by counting the number of fibroblasts in each group. The results showed that the highest number of fibroblasts was found in Bidara leaf (Ziziphus mauritiana) viscous extract group compared to other groups. The difference number of fibroblast cells of different concentrations is due to the effect of active substances contained in bidara leaf, like alkaloids, terpenoids, saponins, phenolics, flavonoids, and tannins. The active substances in bidara leaf could improve wound healing due to antibacterial and anti-inflammatory properties. It can be concluded that bidara leaf viscous extract gel is more effective to increase the number of fibroblast cells on incision wounds of the experimental animals